Table 1.
Characteristics of the ‘203 primary resection lung adenocarcinoma specimens’ and correlations between the patients harboring EML4-ALK mutation.
|
|
Total (%) |
EML4-ALK Rearrangement |
P |
|
|
Positive (%) |
Negative (%) |
|||
|
Age (mean±SD, years) |
63±8.84 |
62.11±8.89 |
62.4±12.2 |
0.500 |
|
Gender Male Female |
150 (73.9) 53 (26.1) |
3 (2) 2 (3.8) |
147 (98) 51 (96.2) |
0.608 |
|
Size mean±SD (cm) |
3.7±2.5 |
5.54±3.34 |
3.61±2.02 |
0.037 |
|
Pathological T-stage T1A T1B T1C T2A T2B T3 T4 |
7 (3.4) 23 (11.3) 32 (15.8) 75 (37) 23 (11.3) 25 (12.3) 18 (8.9) |
|
|
|
|
Pathological N-stage Nx N0 N1 N2 |
37 (18.2) 108 (53.2) 37 (18.2) 21 (3.7) |
1 (0.8) 2 (1.9) 11 (0.8) 1 (4.8) |
36 (97.2) 106 (98.1) 36 (97.2) 20 (95.2) |
0.611 |
|
Visseral pleural invasion Positive Negative |
111 (54.7) 92 (45.3) |
3 (2.8) 2 (2.2) |
109 (97.2) 90 (97.8) |
0.308 |
|
Smoking history Never Ever |
43 (21.2) 160 (78.8) |
3 (7) 2 (1.3) |
40 (93) 158 (98.7) |
0.064 |
|
Stage IA IB IIA IIB IIIA IIIB IV Unknown |
47 (23.1) 52 (25.6) 23 (11.3) 14 (6.8) 22 (10.8) 3 (1.5) 24 (11.8) 18 (9.1) |
Stage I 2 (2.1) Stage II, III, IV 3 (2.9) |
Stage I 97 (97.9) Stage II, III, IV 101 (97.1) |
0.489 |
|
Dominant pattern Acinar Papillary Lepidic Micropapillary Solid Fetal Mucinous Enteric Adenosquamous |
118 (58.1) 29 (14.3) 6 (3.5) 4 (2) 30 (14.8) 1 (0.2) 12 (5.9) 1 (0.2) 2 (1) |
Acinar 1 (2.4) Solid 4 (13.4) |
Acinar 117 (97.6) Solid 26 (86.6) |
0.008 |