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. 2023 Sep 19;13:15505. doi: 10.1038/s41598-023-42833-4

Table 2.

RMSD, RMSF, RoG, SASA, and number of H-bonds of top-ranked compounds against CviR of C. violaceum after 160 ns MD simulation.

Ligands RMSD (Å) RMSF (Å) RoG (Å) SASA (Å) Intramolecular H-bond
Unbound CviR 1.49 ± 0.15 1.24 ± 0.52 16.07 ± 0.09 9924.08 ± 242.72 91.74 ± 6.62
Coniochaetone A 2.01 ± 0.31 1.23 ± 0.59 16.21 ± 0.12 9865.82 ± 248.22 91.44 ± 6.53
Coniochaetone B 1.90 ± 0.31 1.24 ± 0.66 16.13 ± 0.10 9837.93 ± 245.79 92.70 ± 6.45
Coniochaetone K 1.77 ± 0.30 1.10 ± 0.58 16.21 ± 0.10 10,050.80 ± 238.61 91.82 ± 6.71
Viriditoxin SC-30532 1.79 ± 0.22 1.26 ± 0.58 16.27 ± 0.11 10,236.71 ± 271.44 93.08 ± 6.76
Citrinin H1 1.93 ± 0.34 1.27 ± 0.64 16.23 ± 0.12 10,297.42 ± 264.52 86.98 ± 6.49
(3S)-3,8-Dihydroxy-6,7-dimethyl-alpha-tetralone 2.06 ± 0.36 1.44 ± 0.71 16.21 ± 16.21 10,137.81 ± 320.28 89.96 ± 6.65
Azithromycin 2.09 ± 0.43 1.34 ± 0.65 16.47 ± 0.12 10,388.94 ± 278.36 92.57 ± 6.94