Skip to main content
. 2023 Sep 19;6:953. doi: 10.1038/s42003-023-05332-w

Fig. 4. Distribution of amino acids of Abs/Nbs over ES.

Fig. 4

a Heat map of amino acids of Ab H chains on each ES, magenta indicates the frequency of the amino acids. b Heat map of amino acids of nanobody on each ES, blue indicates the frequency of the amino acids. Top triplets are those most frequently observed amino acids of Abs/Nbs on each ES. c The usage of amino acids of antibody H chains (magenta) and nanobodies (blue) in interacting with RBD is plotted in descending order (percentage). YSR are most frequently observed amino acids both for Ab and Nb. d Usage of amino acids in CDR3 loops (purple for Abs; light blue for Nbs). W of Nbs has relatively higher percentage in comparison to Abs both overall and for CDR3 loop. e Usage of amino acids in CDR2 loops (marine for Ab; cyan for Nb). SGY are most frequently used amino acids for Ab, SYD are most frequently used amino acids for Nb. f Usage of amino acids in CDR1 loops (orange for Ab; green for Nb). STYN are most frequently used amino acids for Ab, TY are most frequently used amino acids for Nb.