Table 1.
Comparison of sensitivity and specificity rates of index tests in different studies
| Study | Year | Study type | Study population | Mean of age, year ± SD | Type of LVV | CRP/ESR available | Reference standard | Index test | Performance |
|---|---|---|---|---|---|---|---|---|---|
| Blockmans et al. | 2000 | Retrospective | 69 | 69 ± 9 | GCA | Yes | Clinical criteria and positive TAB | Visual intensity of FDG uptake | Sensitivity: 56% |
| Specificity: 98% | |||||||||
| PPV: 93% | |||||||||
| NPV: 80% | |||||||||
| Soussan et al. | 2015 | Meta-analysis | 127 | 55.4 ± 11 | GCA | Yes | ACR criteria or positive TAB | Visual intensity of FDG uptake | GCA: |
| Sensitivity: 90% | |||||||||
| Specificity: 98% | |||||||||
| PRL: 28.7 | |||||||||
| NRL: 0.15 | |||||||||
| Lariviere et al. | 2016 | Prospective | 24 | 72.7 (51-85) | GCA | Yes | Positive TAB | Visual intensity of FDG uptake | Sensitivity: 66% |
| Specificity: 100% | |||||||||
| PPV: 100% | |||||||||
| NPV: 64% | |||||||||
| Sammel et al. | 2019 | Prospective | 64 | 69 (50-90) | GCA | Yes | Positive TAB | Visual intensity of FDG uptake | Sensitivity: 92% |
| Specificity: 85% | |||||||||
| PPV: 61% | |||||||||
| NPV: 98% | |||||||||
| AUC: 88% | |||||||||
| Santhosh et al. | 2014 | Retrospective | 51 | 30 ± 12 | TA | Yes | ACR criteria | Intensity of FDG uptake | Sensitivity: 83% |
| Specificity: 90% |
PPV, positive predictive value; NPV, negative predictive value; PLR, positive likehood ratio; NLR, negative likehood ratio; AUC, area under the curve; TAB, temporal artery biopsy.