TABLE 1.
Susceptibilities of 83 opportunistic filamentous and dimorphic fungi to SCH56592, MK-0991, and LY303366a
| Fungus (no. tested) | Antifungal agent | MIC range (μg/ml) | Geometric mean MIC (μg/ml) | MFC range (μg/ml) |
|---|---|---|---|---|
| Opportunistic filamentous fungi | ||||
| Acremonium strictum (1) | SCH56592 | 0.06 | NDb | >16 |
| MK-0991 | 0.5 | ND | >16 | |
| LY303366 | >16 | ND | NDc | |
| Aspergillus flavus (11) | SCH56592 | 0.03–0.12 | 0.10 | 0.25–2 |
| MK-0991 | 0.5 | 0.5 | ND | |
| LY303366 | <0.03–0.12 | 0.08 | ND | |
| Aspergillus fumigatus (13)d | SCH56592 | <0.03–1.0 | 0.13 | 0.25–>16 |
| MK-0991 | 0.5–>16 | 2.15 | ND | |
| LY303366 | 0.06 | 0.06 | ND | |
| Aspergillus terreus (2) | SCH59592 | <0.03–0.5 | ND | 1.0 |
| MK-0991 | 0.5 | ND | ND | |
| LY303366 | <0.03 | ND | ND | |
| Bipolaris spp.e (6) | SCH56592 | 0.06–0.25 | 0.14 | 0.5–4 |
| MK-0991 | 1.0–2 | 1.7 | ND | |
| LY303366 | 1.0–4 | 2.7 | ND | |
| Cladophialophora bantiana (5) | SCH56592 | <0.03–0.06 | 0.05 | 0.06–0.5 |
| MK-0991 | 2–8 | 3.6 | 8–>16 | |
| LY303366 | 1.0–4 | 2 | 8–>16 | |
| Fusarium oxysporum (6) | SCH56592 | 1–>16 | 4.16 | 2–>16 |
| MK-0991 | >16 | >16 | ND | |
| LY303366 | 16–>16 | >16 | ND | |
| Fusarium solani (6) | SCH56592 | >16 | >16 | ND |
| MK-0991 | 16–>16 | >16 | ND | |
| LY303366 | >16 | >16 | ND | |
| Phialophora spp.f (5) | SCH56592 | 0.06–1.0 | 0.4 | 2–>16 |
| MK-0991 | 1.0–16 | 2.8 | >16 | |
| LY303366 | 1.0–>16 | 9 | >16 | |
| Pseudallescheria boydii (6) | SCH56592 | 0.5–2 | 1.0 | >16 |
| MK-0991 | 0.5–4 | 1.3 | >16 | |
| LY303366 | 2–4 | 2.5 | >16 | |
| Rhizopus arrhizus (5) | SCH56592 | 2 | 2 | 2–16 |
| MK-0991 | >16 | >16 | ND | |
| LY303366 | >16 | >16 | ND | |
| Scedosporium prolificans (2) | SCH56592 | >16 | ND | ND |
| MK-0991 | 4–8 | ND | >16 | |
| LY303366 | 4 | ND | ND | |
| Dimorphic fungi | ||||
| Blastomyces dermatitidis (5) | SCH56592 | <0.03–0.06 | 0.05 | 2–16 |
| MK-0991 | 0.5–8 | 2 | ND | |
| LY303366 | 2–8 | 4 | ND | |
| Histoplasma capsulatum (5) | SCH56592 | <0.03–0.06 | 0.04 | 0.5–2 |
| MK-0991 | 0.5–4 | 1.3 | ND | |
| LY303366 | 2–4 | 3.6 | ND | |
| Sporothrix schenckii (5) | SCH56592 | 0.12–1.0 | 0.7 | 1–4 |
| MK-0991 | 1.0–>16 | 5.4 | ND | |
| LY303366 | 0.25–>16 | 3.9 | ND | |
| Total (83) |
a
Visual MICs-2 correspond to prominent growth inhibition (approximately ≤50% of that of the growth control).
b
For the geometric mean MIC column, ND indicates not obtained.
c
For the MFC range column, ND indicates not done.
d
The set included two isolates resistant to itraconazole (MICs, >8 μg/ml).
e
Bipolaris hawaiiensis and Bipolaris spicifera.
f
Phialophora parasitica, Phialophora repens, and Phialophora verrucosa.