TABLE 2.

Susceptibilities of 104 selected pathogenic yeasts to SCH56592, MK-0991, and LY303366 as determined by a spectrophotometric procedure

Fungus (no. tested)	Antifungal agent	MIC range (μg/ml)	MIC50 (μg/ml)	MIC90 (μg/ml)	MFC range (μg/ml)	MFC90 (μg/ml)
C. albicans (10)a	SCH56592	0.06–1.0 (>16)b	0.5	1.0	NDc	NDc
	MK-0991	0.25–2	0.5	1.0	0.5–>16	2
	LY303366	<0.03–0.25	0.06	0.25	0.25–4	1.0
C. albicans (10)d	SCH56592	<0.03–0.06 (>16)	<0.03	<0.03	ND	ND
	MK-0991	0.25–2	0.5	1.0	0.25–1.0	1.0
	LY303366	<0.03–0.25 (<0.03)	0.06	0.06	0.25–1.0	0.5
C. glabrata (12)	SCH56592	<0.03–4	1.0	4	>16	≥16
	MK-0991	0.5–2	0.5	1.0	1–4	2
	LY303366	0.06–0.25	0.12	0.25	0.12–1.0	0.5
C. guilliermondii (8)	SCH56592	<0.03–0.25 (0.06–4)	0.25	NDe	4–>16	ND
	MK-0991	>16 (0.5–8)	2	ND	ND	ND
	LY303366	0.25–4	2	ND	4–8	ND
C. krusei (13)	SCH56592	0.5–1.0	1.0	1.0	1.0–2	1.0
	MK-0991	0.5–4	1.0	2	1.0–2	2
	LY303366	0.12–1.0 (<0.03–0.5)	0.5	1.0	0.25–1.0	1.0
C. lusitaniae (12)	SCH56592	<0.03–0.25 (<0.03–1.0)	0.06	0.06	0.06–4	0.25
	MK-0991	1.0–4	1.0	2	1.0–4	1.0
	LY303366	0.25–2 (0.06–2)	1.0	2	1.0–2	2
C. parapsilosis (12)	SCH59592	0.06–0.5 (0.06–>16)	0.25	0.5	1.0–>16	8
	MK-0991	0.5–2 (2–4)	1.0	2	1.0–>16	2
	LY303366	0.5–2	2	2	1.0–4	4
C. tropicalis (12)	SCH56592	0.06–8 (>16)	0.25	0.25	ND	ND
	MK-0991	0.5–2 (<0.03–2)	1.0	1.0	0.5–1.0	1.0
	LY303366	0.12–0.5 (<0.03–0.2)	0.25	0.5	0.12–1.0	1.0
C. neoformans (10)	SCH56592	0.25–0.5	0.25	0.25	0.25–0.5	0.5
	MK-0991	16–>16	>16	>16	ND	ND
	LY303366	>16	>16	>6	ND	ND
T. beigelii (5)	SCH56592	0.12–1.0	1.0	ND	0.5–>16	ND
	MK-0991	16–>16	>16	ND	>16	ND
	LY303366	>16	>16	ND	ND	ND
Total (104)

^aFluconazole MIC, >16 μg/ml; itraconazole MIC, 0.06 to >8 μg/ml. 

^bValues in parentheses are MIC-0 (SCH56592) and MIC-2 (other agents) endpoints. 

^cFor MFC columns, ND indicates not done. 

^dFluconazole MIC, ≤1.0 μg/ml; itraconazole MIC, <0.03 to 0.06 μg/ml. 

^eFor the MIC₉₀ column, ND indicates not obtained.