TABLE 4.

Summaries of published MIC data for four antifungal agents and for the three investigational agents from this study^a

Species	Antifungal agent	MIC50 (μg/ml)	MIC90 (μg/ml)	Geometric mean MIC (μg/ml)
Yeasts
Candida spp.	Amphotericin B		1–2
	Fluconazole		2–64
	Itraconazole		0.25–2
	Voriconazole		0.06–4
	SCH56592		<0.03–4
	MK-0991		1.0–2
	LY303366		0.06–2
Cryptococcus neoformans	Amphotericin B		1.0
	Fluconazole		16
	Itraconazole		1.0
	Voriconazole		0.12
	SCH56592		0.25
	MK-0991		>16
	LY303366		>16
Trichosporon beigelii	Amphotericin B	2
	Fluconazole	2
	Itraconazole	0.25
	Voriconazole	<0.03
	SCH56592	1.0
	MK-0991	>16
	LY303366	>16
Opportunistic filamentous fungi
Aspergillus spp.	Amphotericin B			1.0–1.07
	Itraconazole			0.1–0.24
	Voriconazole			0.29–0.57
	SCH 56592			0.1–0.13
	MK-0991			0.5–2.15
	LY303366			0.06–0.08
Bipolaris spp.	Amphotericin B			0.65
	Itraconazole			0.06
	Voriconazole			0.33
	SCH56592			0.14
	MK-0991			1.7
	LY303366			2.7
Fusarium spp.	Amphotericin B			1.31–2
	Itraconazole			8
	Voriconazole			4–10.5
	SCH56592			4.16–>16
	MK-0991			>16
	LY303366			>16
Pseudallescheria boydii	Amphotericin B			2.6
	Itraconazole			0.76
	Voriconazole			0.33
	SCH56592			1.0
	MK-0991			1.3
	LY303366			2.5
Rhizopus arrhizus	Amphotericin B			0.57
	Itraconazole			0.43
	Voriconazole			18.37
	SCH56592			2
	MK-0991			>16
	LY303366			>16
Dimorphic fungi
Blastomyces dermatitidis	Amphotericin B			0.14
	Itraconazole			0.06
	Voriconazole			0.1
	SCH56592			0.05
	MK-0991			2
	LY303366			4
Histoplasma capsulatum	Amphotericin B			0.42
	Itraconazole			0.06
	Voriconazole			0.06
	SCH56592			0.04
	MK-0991			1.3
	LY303366			3.6
Sporothrix schenckii	Amphotericin B			1.5
	Itraconazole			0.5
	Voriconazole			16
	SCH56592			0.7
	MK-0991			5.4
	LY303366			3.9

^aData for amphotericin B, fluconazole, itraconazole, and another new triazole, voriconazole, have been published previously (5).