REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, peptides, and recombinant proteins
LPS	Sigma	Cat#L2630-100mg
Electron microscope fixative fluid	Wuhan Servicebio Biotechnology	Cat#G1102-100ML
TransZol	TransGen Biotech	Cat#ET111-01-V2
Critical commercial assays
BCA Protein Assay Kit	Bio-Rad	Cat#5000002
High pH Reversed-Phase Peptide Fractionation Kit	Thermo Scientific	Cat#84868
NovoScript Plus All-in-one 1st Strand cDNA Synthesis SuperMix	Novoprotein	Cat#E047
PerfectStart Green qPCR SuperMix	TransGen Biotech	Cat#AQ611-01
Deposited data
RNA-seq raw and analyzed data	This paper	GEO: GSE229925
Proteomics raw and analyzed data	This paper	ProteomeXchange ID: PXD041530
Experimental models: Organisms/strains
Mouse: C57BL/6	Hunan SJA Laboratory Animal Co. Ltd	N/A
Rat: Sprague-Dawley	Hunan SJA Laboratory Animal Co. Ltd	N/A
Oligonucleotides
PCR primers (for full sequence, see Table S5)	This paper	Custom primer sets
Software and algorithms
MASCOT engine version 2.2	Matrix Science	https://matrixscience.com
Proteome Discoverer	Thermo Scientific	Cat#OPTON-31101
Broad GSEA software (3.0)	UC San Diego and Broad Institute	http://software.broadinstitute.org/gsea
EnrichmentMap Cytoscape App	Merico et al.35	https://apps.cytoscape.org/apps/enrichmentmap
Metascape	Zhou et al.36	https://metascape.org/gp/index.html#/main/step1
Other
Easy nLC	Thermo Scientific	Cat#LC140
Q exactive mass spectrometer	Thermo Scientific	Cat#IQLAAEGAAPFALGMAZR
Vivid IQ ultrasound	GE	https://www.gehealthcare.com/zh-cn/products/ultrasound/vivid/vivid-iq-ultra-edition
QuantStudio5 Real-Time PCR system	Applied Biosystems	Cat#A36320