Table 1.

Mendelian randomization for sex hormones (androsterone sulfate, DHEAS, estradiol, SHBG and total testosterone) and their estimated effect on Alzheimer’s disease status, stratified by sex. We adjusted for multiple testing using the Benjamini-Hochberg FDR P-value.

		Males					Females					Total
Exp	N SNP	OR	LL	UL	P	FDR P	OR	LL	UL	P	FDR P	OR	LL	UL	P	FDR P
Andro	3	0.69	0.46	1.02	0.06	0.10	0.84	0.58	1.23	0.38	0.47	0.78	0.59	1.03	0.08	0.13
DHEAS	6	0.56	0.38	0.85	0.01	0.03	0.82	0.59	1.13	0.22	0.47	0.71	0.55	0.92	0.01	0.05
E2	8	0.91	0.59	1.40	0.66	0.82	0.84	0.64	1.11	0.23	0.47	0.87	0.70	1.09	0.22	0.27
SHBG	250	0.98	0.67	1.42	0.91	0.91	0.97	0.72	1.30	0.85	0.85	0.97	0.77	1.23	0.83	0.83
Tot T	120	0.53	0.32	0.88	0.01	0.03	0.82	0.52	1.28	0.38	0.47	0.69	0.48	0.99	0.04	0.10

Abbreviations: N: Number of SNPs used in the MR analysis; OR: Odds ratio; LL: 95%CI Lower Limit; UL: 95%CI Upper Limit; P: P-value; FDR P: False Discovery Rate P-value; Andro: Androsterone sulfate; DHEAS: dehydroepiandrosterone sulfate; E2: Estradiol; SHBG: Sex Hormone Binding Globulin; Tot T: Total Testosterone.