Table 2a.

Bidirectional Mendelian randomization analysis for AD status and its estimated effects on sex hormones (androsterone sulfate, DHEAS, estradiol, SHBG, and total testosterone). The genetic variants for the MR analysis were derived from the ADGC GWAS, using the sex-stratified summary statistics.

	Males						Females						Total
Exp	N SNP	OR	LL	UL	P	FDR P	N SNP	OR	LL	UL	P	FDR P	N SNP	OR	LL	UL	P	FDR P
AD--> Andro	1	1.00	0.98	1.02	0.82	0.82	2	1.01	0.99	1.02	0.56	0.59	5	1.01	0.99	1.03	0.44	0.72
AD--> DHEAS	1	0.99	0.97	1.01	0.32	0.79	2	0.98	0.96	1.00	0.03	0.08	5	0.98	0.96	1.00	0.03	0.07
AD--> E2	1	1.00	0.98	1.03	0.76	0.82	2	0.99	0.97	1.01	0.54	0.59	5	0.99	0.98	1.01	0.61	0.72
AD--> SHBG	1	1.64	1.39	1.92	2×10−9	9×10−9	2	1.48	1.10	2.00	0.01	0.05	5	1.48	1.18	1.85	7×10−4	3×10−3
AD--> Tot T	1	1.00	0.99	1.02	0.61	0.82	2	1.00	0.99	1.02	0.59	0.59	5	1.00	0.99	1.02	0.72	0.72