TABLE 4.
TOPKAT prediction of the tested alkamides from Piper nigrum fruits.
| Compound | Ames prediction | Rat oral LD50 | Rat chronic LOAEL | Skin irritancy | Ocular irritancy | Rat male FDA | Rat female FDA |
|---|---|---|---|---|---|---|---|
| 1 | Non-mutagen | 0.699537 | 0.00656405 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 2 | Non-mutagen | 0.773324 | 0.00559316 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 3 | Non-mutagen | 1.07948 | 0.00295513 | Severe | None | Non-carcinogen | Non-carcinogen |
| 4 | Non-mutagen | 0.960009 | 0.00301254 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 5 | Non-mutagen | 1.63813 | 0.00248574 | Severe | None | Non-carcinogen | Non-carcinogen |
| 6 | Non-mutagen | 1.26178 | 0.00255341 | Mild | None | Non-carcinogen | Non-carcinogen |
| 7 | Non-mutagen | 0.831267 | 0.0163319 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 8 | Non-mutagen | 1.15027 | 0.00755798 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 9 | Non-mutagen | 1.99221 | 0.00801701 | Mild | None | Non-carcinogen | Non-carcinogen |
| 10 | Non-mutagen | 2.63527 | 0.011869 | Mild | None | Non-carcinogen | Non-carcinogen |
| 11 | Non-mutagen | 2.69314 | 0.0546533 | Mild | None | Non-carcinogen | Non-carcinogen |
| 12 | Non-mutagen | 1.47311 | 0.00205941 | Severe | Severe | Non-carcinogen | Non-carcinogen |
| 12 | Non-mutagen | 2.22155 | 0.0115162 | Mild | None | Non-carcinogen | Non-carcinogen |
| 13 | Non-mutagen | 2.4754 | 0.0239389 | Mild | None | Non-carcinogen | Non-carcinogen |
| 14 | Non-mutagen | 2.26097 | 0.0337304 | Mild | None | Non-carcinogen | Single-carcinogen |
| 15 | Non-mutagen | 2.24329 | 0.0163692 | Mild | None | Non-carcinogen | Non-carcinogen |
| 16 | Non-mutagen | 2.07479 | 0.0230936 | Mild | None | Non-carcinogen | Non-carcinogen |
| 17 | Non-mutagen | 2.12355 | 0.182032 | Mild | None | Non-carcinogen | Non-carcinogen |
| 18 | Mutagen | 0.871606 | 0.040755 | None | Mild | Multi-carcinogen | Non-carcinogen |
| 19 | Non-mutagen | 3.77773 | 0.00916935 | Severe | None | Non-carcinogen | Non-carcinogen |
| 20 | Mutagen | 2.20834 | 0.296757 | None | Mild | Multi-carcinogen | Non-carcinogen |
| 21 | Mutagen | 0.58896 | 0.178629 | None | Mild | Single-carcinogen | Non-carcinogen |
| 22 | Mutagen | 0.739978 | 0.207833 | None | Mild | Single-carcinogen | Single-carcinogen |
| 23 | Non-mutagen | 2.68972 | 0.0248511 | Mild | None | Non-carcinogen | Non-carcinogen |
| 24 | Non-mutagen | 0.720878 | 0.0463523 | Severe | Severe | Non-carcinogen | Non-carcinogen |
| 25 | Non-mutagen | 3.52932 | 0.045389 | Mild | None | Non-carcinogen | Single-carcinogen |
| 26 | Non-mutagen | 0.134026 | 0.000322202 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 27 | Non-mutagen | 1.85205 | 0.0025682 | Severe | None | Non-carcinogen | Non-carcinogen |
| 28 | Non-mutagen | 1.5891 | 0.0311345 | Mild | Severe | Non-carcinogen | Single-carcinogen |
| 29 | Non-mutagen | 5.76115 | 0.0157735 | None | Severe | Non-carcinogen | Non-carcinogen |
| 30 | Non-mutagen | 1.32768 | 0.105859 | None | Severe | Non-carcinogen | Non-carcinogen |
| 31 | Non-mutagen | 0.147778 | 0.000209789 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 32 | Non-mutagen | 0.442598 | 0.000262114 | Mild | Severe | Non-carcinogen | Non-carcinogen |
| 33 | Non-mutagen | 2.63857 | 0.00543712 | Mild | None | Non-carcinogen | Non-carcinogen |
| 34 | Non-mutagen | 1.54443 | 0.00765291 | Mild | Severe | Non-carcinogen | Non-carcinogen |
| 35 | Non-mutagen | 0.773324 | 0.00559316 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 36 | Non-mutagen | 0.922921 | 0.0139764 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 37 | Non-mutagen | 1.15027 | 0.00755798 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 38 | Non-mutagen | 0.257543 | 0.00739208 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 39 | Non-mutagen | 1.37968 | 0.00425613 | Mild | None | Non-carcinogen | Non-carcinogen |
| 40 | Non-mutagen | 1.78122 | 0.00412023 | Severe | None | Non-carcinogen | Non-carcinogen |
| 41 | Non-mutagen | 0.11136 | 0.00362488 | None | Mild | Multi-carcinogen | Multi-carcinogen |
| 42 | Non-mutagen | 2.62323 | 0.00647272 | Mild | None | Non-carcinogen | Non-carcinogen |
| 43 | Non-mutagen | 2.67955 | 0.025341 | None | Severe | Non-carcinogen | Non-carcinogen |
| 44 | Non-mutagen | 1.75339 | 0.154136 | None | Severe | Non-carcinogen | Non-carcinogen |
| 45 | Non-mutagen | 1.75339 | 0.154136 | None | Severe | Non-carcinogen | Non-carcinogen |
| 46 | Non-mutagen | 0.743252 | 0.0132063 | Severe | Mild | Multi-carcinogen | Non-carcinogen |
| 47 | Non-mutagen | 2.7863 | 0.059828 | Severe | Mild | Non-carcinogen | Single-carcinogen |
| 48 | Non-mutagen | 2.89133 | 0.0793748 | Severe | Mild | Non-carcinogen | Single-carcinogen |
| 49 | Non-mutagen | 3.12925 | 0.0580334 | Mild | None | Non-carcinogen | Single-carcinogen |
| 50 | Non-mutagen | 3.36806 | 0.0179123 | Mild | Severe | Non-carcinogen | Non-carcinogen |
| 51 | Non-mutagen | 1.82564 | 0.0184801 | Mild | None | Non-carcinogen | Single-carcinogen |
| 53 | Non-mutagen | 3.35849 | 0.127313 | Severe | Mild | Non-carcinogen | Non-carcinogen |
| 54 | Mutagen | 1.01416 | 0.22397 | None | Mild | Multi-carcinogen | Non-carcinogen |
| 55 | Non-mutagen | 4.81789 | 0.0635814 | Mild | None | Non-carcinogen | Single-carcinogen |
| 56 | Non-mutagen | 1.04811 | 0.00760525 | Severe | Severe | Non-carcinogen | Non-carcinogen |
| 57 | Non-mutagen | 0.699537 | 0.00656405 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 58 | Non-mutagen | 0.699537 | 0.00656405 | Mild | Mild | Non-carcinogen | Non-carcinogen |
| 59 | Non-mutagen | 0.699537 | 0.00656405 | Mild | Mild | Non-carcinogen | Non-carcinogen |