TABLE 2.

Clinical and therapeutic differences between histaminergic and non‐histaminergic angioedema. ⁵ , ²⁰ , ²¹

Clinical feature	Histamine‐mediated angioedema	Bradykinin‐mediated AAE	Bradykinin‐mediated HAE
Age of first symptoms	Any	4th – 6th decade	1st–2nd decade
Onset	Rapid (minutes)	Slow (hours)	Slow (hours)
Duration	12–14 h	48–72 h	48–72 h
Family history	No	No	Yes
Cutaneous involvement (other than angioedema)	Wheals present/history of recurrent wheals	Erythema marginatum very rarely	Erythema marginatum prior to an attack is frequent
Predominant location	Face (eyelids/lips)	Face, peripheral, upper airways, GI tract	Face, peripheral, upper airways, GI tract
Past recurrent abdominal pain/swelling	No	Yes	Yes
Anti‐allergy therapies	Effective	Not effective	Not effective

Abbreviations: AAE, acquired angioedema; GI, gastrointestinal; HAE, hereditary angioedema.