Table 2.
Performance of the GICA using different diagnostic tests as reference.
| GICA† | Reference test | % Sensitivity (95% CI) | % Specificity (95% CI) | % PPV (95% CI) | % NPV (95% CI) | % Accuracy (95% CI) | Kappa index (95% CI) | |
|---|---|---|---|---|---|---|---|---|
| + | − | |||||||
| KK | ||||||||
| + | 90 | 161 | 83.3 (74.9–89.8) | 47.0 (41.3–52.8) | 35.9 (29.9–42.1) | 88.8 (82.9–93.2) | 56.6 (51.6–61.4) | 0.213 (0.143–0.283) |
| − | 18 | 143 | ||||||
| F_ddPCR | ||||||||
| + | 198 | 53 | 64.5 (58.9–69.9) | 49.5 (39.6–59.5) | 78.9 (73.3–83.8) | 32.3 (25.2–40.1) | 60.7 (55.8–65.4) | 0.119 (0.026–0.213) |
| − | 109 | 52 | ||||||
| SR_ddPCR | ||||||||
| + | 177 | 74 | 64.0 (57.8–69.6) | 45.2 (36.6–54.0) | 70.5 (64.5–76.1) | 37.9 (30.4–45.9) | 57.8 (52.8–62.6) | 0.087 (−0.010–0.183) |
| − | 100 | 61 | ||||||
| U_ddPCR | ||||||||
| + | 123 | 128 | 62.8 (55.6–69.5) | 40.7 (34.1–47.6) | 49.0 (42.7–55.4) | 54.7 (46.6–62.5) | 51.2 (46.3–56.1) | 0.035 (−0.058–0.128) |
| − | 73 | 88 | ||||||
| SL_ddPCR | ||||||||
| + | 70 | 181 | 66.7 (56.8–75.6) | 41.0 (35.5–46.8) | 27.9 (22.4–33.9) | 78.3 (71.1–84.4) | 47.6 (42.7–52.5) | 0.053 (−0.02–0.126) |
| − | 35 | 126 | ||||||
| POC-CCA† | ||||||||
| + | 39 | 212 | 76.5 (62.5–97.2) | 41.3 (36.2–46.6) | 15.5 (11.3–20.6) | 92.6 (87.3–96.1) | 43.2 (38.4–48.1) | 0.066 (0.016–0.116) |
| − | 12 | 149 | ||||||
| Sj23-LHD-ELISA# | ||||||||
| + | 86 | 165 | 85.2 (76.7–91.4) | 47.0 (41.3–52.7) | 34.3 (28.4–40.5) | 90.7 (85.1–94.7) | 56.3 (51.4–61.2) | 0.214 (0.147–0.281) |
| − | 15 | 146 | ||||||
| SjSAP4-ELISA# | ||||||||
| + | 241 | 10 | 92.0 (88.0–95.0) | 93.3 (88.1–96.8) | 96.0 (92.8–98.1) | 87.0 (80.8–91.7) | 92.5 (89.5–94.8) | 0.840 (0.786–0.894) |
| − | 21 | 140 | ||||||