Table 2.
Cambridge cohorts: Hypothalamic nuclei volumetric between group results normalised to ICV.
| Control mean (SD) | Overweight mean (SD) | Obese (SD) | BN mean (SD) | AN mean (SD) | AN/BN matched control mean (SD) | Overweight-Control p-value (FDR) | Obese-Control p-value (FDR) | BN-Control p-value (FDR) | AN-Control p-value (FDR) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Hypothalamic volumes (left hemisphere) | ||||||||||
| Anterior-inferior | 0.0012 (0.0003) | 0.0013 (0.0002) | 0.0014 (0.0003) | 0.0011 (0.0003) | 0.0011 (0.0003) | 0.0012 (0.0003) | – | * (*) | – | – |
| Anterior-superior | 0.0017 (0.0004) | 0.0017 (0.0002) | 0.0017 (0.0003) | 0.0015 (0.0002) | 0.0014 (0.0003) | 0.0015 (0.0003) | – | – | – | – |
| Posterior | 0.0081 (0.0019) | 0.0079 (0.0007) | 0.0083 (0.0009) | 0.0083 (0.0012) | 0.0080 (0.0009) | 0.0081 (0.0010) | – | – | – | – |
| Tubular inferior | 0.0092 (0.0024) | 0.0092 (0.0010) | 0.0098 (0.0009) | 0.0100 (0.0010) | 0.0100 (0.0010) | 0.0096 (0.0009) | – | – | – | – |
| Tubular superior | 0.0077 (0.0018) | 0.0077 (0.0007) | 0.0077 (0.0008) | 0.0077 (0.0010) | 0.0074 (0.0007) | 0.0078 (0.0008) | – | – | – | – |
| Whole | 0.0280 (0.0065) | 0.0276 (0.0019) | 0.0289 (0.0016) | 0.0287 (0.0024) | 0.0280 (0.0022) | 0.0282 (0.0024) | – | – | – | – |
| Hypothalamic volumes (right hemisphere) | ||||||||||
| Anterior-inferior | 0.0011 (0.0003) | 0.0011 (0.0002) | 0.0011 (0.0002) | 0.0009 (0.0002) | 0.0010 (0.0002) | 0.0009 (0.0002) | – | – | – | – |
| Anterior-superior | 0.0017 (0.0005) | 0.0017 (0.0002) | 0.0017 (0.0003) | 0.0016 (0.0003) | 0.0015 (0.0003) | 0.0016 (0.0003) | – | – | – | – |
| Posterior | 0.0076 (0.0018) | 0.0077 (0.0008) | 0.0085 (0.0013) | 0.0082 (0.0014) | 0.0081 (0.0009) | 0.0082 (0.0011) | – | ** (*) | – | – |
| Tubular inferior | 0.0086 (0.0019) | 0.0087 (0.0008) | 0.0089 (0.0010) | 0.0089 (0.0009) | 0.0088 (0.0009) | 0.0088 (0.0008) | – | – | – | – |
| Tubular superior | 0.0083 (0.0023) | 0.0082 (0.0008) | 0.0082 (0.0008) | 0.0081 (0.0010) | 0.0078 (0.0009) | 0.0080 (0.0008) | – | – | – | – |
| Whole | 0.0275 (0.0065) | 0.0274 (0.0021) | 0.0285 (0.0019) | 0.0278 (0.0028) | 0.0272 (0.0023) | 0.0275 (0.0023) | – | – | – | – |
Means, standard deviations (SD) and t-test p-value results of hypothalamic volumes as normalised§ to intracranial volume (ICV) [§Hypothalamic volume as a percentage of ICV]; (- = p > 0.5, * = p < 0.05, ** = p < 0.01, *** = p < 0.001). Bracketed significance indicator denotes FDR corrected p-value. Control groups = BMI 18.5 – 24.9, overweight = BMI 25 – 29.9, obese = BMI 30 +.