Table 4.
HCP Young Adults: Hypothalamic nuclei volumetric between group results normalised to ICV.
| Underweight mean (SD) | Normal weight mean (SD) | Overweight mean (SD) | Obese mean (SD) | Underweight – normal weight p-value (FDR) | Overweight – normal p-value (FDR) | Obese – normal p-value (FDR) | BMI > 24.9 – normal weight p-value (FDR) | |
|---|---|---|---|---|---|---|---|---|
| Hypothalamic volumes (left hemisphere) | ||||||||
| Anterior-inferior | 0.0011 (0.0003) | 0.0011 (0.0003) | 0.0011 (0.0003) | 0.0011 (0.0003) | – | – | * (-) | – |
| Anterior-superior | 0.0015 (0.0002) | 0.0015 (0.0003) | 0.0015 (0.0003) | 0.0016 (0.0003) | – | – | * (-) | – |
| Posterior | 0.0069 (0.0007) | 0.0073 (0.0009) | 0.0074 (0.0010) | 0.0076 (0.0011) | – | – | ** (**) | * (-) |
| Tubular inferior | 0.0086 (0.0009) | 0.0090 (0.0012) | 0.0091 (0.0012) | 0.0091 (0.0012) | – | – | – | * (-) |
| Tubular superior | 0.0072 (0.0007) | 0.0073 (0.0009) | 0.0075 (0.0009) | 0.0075 (0.0010) | – | ** (*) | ** (*) | *** (**) |
| Whole | 0.0254 (0.0021) | 0.0262 (0.0028) | 0.0267 (0.0029) | 0.0270 (0.0027) | – | * (-) | *** (**) | ** (*) |
| Hypothalamic volumes (right hemisphere) | ||||||||
| Anterior-inferior | 0.0011 (0.0003) | 0.0009 (0.0002) | 0.0010 (0.0003) | 0.0010 (0.0003) | * (-) | – | ** (*) | * (*) |
| Anterior-superior | 0.0017 (0.0003) | 0.0016 (0.0003) | 0.0016 (0.0003) | 0.0016 (0.0003) | – | – | * (-) | – |
| Posterior | 0.0073 (0.0008) | 0.0076 (0.0011) | 0.0075 (0.0012) | 0.0078 (0.0012) | – | – | ** (*) | – |
| Tubular inferior | 0.0081 (0.0009) | 0.0084 (0.0012) | 0.0086 (0.0012) | 0.0086 (0.0012) | – | * (-) | – | * (*) |
| Tubular superior | 0.0076 (0.0006) | 0.0076 (0.0010) | 0.0076 (0.0010) | 0.0078 (0.0011) | – | – | ** (*) | * (-) |
| Whole | 0.0258 (0.0021) | 0.0260 (0.0029) | 0.0263 (0.0031) | 0.0268 (0.0034) | – | – | ** (**) | * (*) |
Means, standard deviations (SD) and t-test p-value results of HCP young adult hypothalamic volumes as normalised§ to intracranial volume (ICV) [§Hypothalamic volume as a percentage of ICV]; (- = p > 0.05, * = p < 0.05, ** = p < 0.01, *** = p < 0.001). Bracketed significance indicator denotes FDR corrected p-value. Underweight = BMI < 18.49, normal weight = BMI 18.5 – 24.9, overweight = BMI 25 – 29.9, obese = BMI 30 +.