Table 2.

Association of functional OATP1B1 phenotypes with phenotypes of statin intolerance

Genotype-determined phenotype of OATP1B1 transporter	GSI	SRM	SRSR
Increased function	0.79 (0.24–2.00), P = 0.63	0.85 (0.20–2.39), P = 0.79	1.29 (0.20–4.55), P = 0.73
Normal function	—	—	—
Decreased function	1.29 (0.86–1.93), P = 0.21	1.38 (0.86–2.18), P = 0.17	1.22 (0.56–2.48), P = 0.60
Poor function	2.98 (1.06–7.21), P = 0.024	3.17 (1.17–7.26), P = 0.012	2.67 (0.42–9.63), P = 0.20

Association of functional OATP1B1 phenotypes according to Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines with phenotypes of statin intolerance in all statin users. All models adjusted for age, gender, previous cardiovascular events, statin type, and statin dose.

GSI, general statin intolerance; SRM, statin-related myopathy; SRSR, statin-related suspected rhabdomyolysis.