Table II.
Implicated drugs, predictive scores, and latency
Case patient | Drugs implicated | Indication | SCORTEN score∗ | Alden score | Naranjo score† | Latency‡ (d) | Receiving at time of rash onset§ |
---|---|---|---|---|---|---|---|
1 | Benzylpenicillin | Bacteremia | N/A | N/A | 4 | 18 | Yes |
Ceftriaxone | 33 | ||||||
Vancomycin | 5 | ||||||
2 | Meloxicam | Joint pain | N/A | N/A | 9 | 0 | Yes |
3 | Trimethoprim/sulfamethoxazole | PJP prophylaxis | 2 | 5 | 4 | 38 | Yes |
Pantoprazole | Gastric ulcer prophylaxis | 4 | 38 | ||||
Atorvastatin | Nephrotic syndrome | 4 | 38 | ||||
4 | Allopurinol | Gout | 4 | 6 | 4 | 19 | Yes |
Ibuprofen | 5 |
N/A, Not applicable; PJP, Pneumocystis jiroveci pneumonia.
SCORTEN score to predict mortality in patients with SJS/TEN.12
Naranjo adverse reaction score for determining the likelihood of an adverse drug reaction actually being due to the implicated drug.11
Latency defined as the time between drug commencement and rash onset (days).
Receiving implicated drugs at the onset of rash.