Fig 4.

Clusters of CpGs with high effect sizes for food sensitization association despite non–statistically significant test results may be suggestive of possible genetic effects. A, Clustered CpG sites (examples are highlighted with color) signify DNA sites in close proximity to one another with frequent high effect sizes in the food sensitization analysis. Chromosome 1 (B) and chromosome 5 (C) CpG cluster regions show trimodal distribution of DNAm, likely owing to nearby genetic variants influencing methylation levels.