Table II.
Comparison between characteristics and outcomes of patients diagnosed with FDEIA and non-FDEIA food anaphylaxis
| Characteristic | Food (n = 83) | FDEIA (n = 55) | Non-FDEIA (n = 28) | P value |
|---|---|---|---|---|
| Male sex, no. (%) | 41 (49.4) | 28 (50.9) | 13 (46.4) | .699 |
| Age (y), median (range) | 44 (20-86) | 47 (23-86) | 38 (20-67) | .096 |
| Age at first episode (y) | 35 (1-80) | 38 (15-80) | 31 (1-62) | .046 |
| Delay in diagnosis (y) | 3 (0-26) | 3 (0-26) | 3 (0-17) | .383 |
| Smoker, no. (%) | 8 (9.6) | 4 (7.3) | 4 (14.3) | .433 |
| Asthma and/or COPD, no. (%) | 26 (31.3) | 6 (10.9) | 10 (35.7) | .007 |
| Hypertension, no. (%) | 10 (12.0) | 9 (16.4) | 1 (3.6) | .153 |
| History of chronic urticaria, no. (%) | 16 (19.3) | 20 (36.4) | 6 (21.4) | .165 |
| Clinical presentation, no. (%) | ||||
| Mucocutaneous | 81 (97.6) | 54 (98.2) | 27 (96.4) | 1.000 |
| Cardiovascular | 63 (75.9) | 50 (90.9) | 13 (46.4) | <.001 |
| Respiratory | 47 (56.6) | 26 (47.3) | 21 (75.0) | .016 |
| Gastrointestinal | 14 (16.9) | 9 (16.4) | 5 (17.9) | 1.000 |
| WAO systemic allergic reaction grade, no. (%)∗ | <.001 | |||
| Grade 3 | 13 (15.7) | 1 (1.8) | 12 (42.9) | |
| Grade 4 | 2 (2.4) | 1 (1.8) | 1 (3.6) | |
| Grade 5 | 68 (81.9) | 53 (96.4) | 15 (53.6) | |
| Acute management, no. (%) | ||||
| Paired tryptase sample taken | 24 (28.9) | 16 (29.1) | 8 (28.6) | .961 |
| Significant elevation | 19/24 (79.2) | 13/16 (81.3) | 6/8 (75.0) | 1.000 |
| Adrenaline administered | 45 (54.2) | 30 (54.5) | 15 (53.6) | .933 |
| Discharged with AAI | 47 (56.6) | 30 (54.5) | 17 (60.7) | .592 |
| After allergist review | ||||
| AAI prescribed, no. (%) | 83 (100.0) | 55 (100.0) | 28 (100.0) | N/A |
| Recurrence, no. (%) | 7 (8.4) | 4 (7.3) | 3 (10.7) | .683 |
| Adrenaline administered, no. (%) | 4 (4.8) | 1 (1.8) | 3 (10.7) | .109 |
| Follow-up duration (y), median (range) | 1.83 (0.20-5.69) | 1.76 (0.20-5.69) | 2.03 (0.20-3.97) | .677 |
Boldface indicates statistical significance (P < .05).
COPD, Chronic obstructive pulmonary disease; NA, not available; WAO, World Allergy Organization.
∗
In this classification, anaphylaxis includes only grade 3 to grade 5 reactions.