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. 2023 Sep 5;28(4):196. doi: 10.3892/mmr.2023.13083

Figure 4.

Figure 4.

miR-637 inhibits the metastasis of HKF cells by suppressing MMP2. (A and B) After overexpression of miR-637 in HKF cells, transwell assays with or without matrigel were performed. Cells were counted and results represent the mean ± standard deviation of three experiments (magnification, ×200). **P<0.01 vs. control. (C and D) After downregulation of miR-637 in HKF cells, transwell assays with or without matrigel were performed. Cells were counted and results represent the mean ± SD of three experiments. **P<0.01 vs. control. (E and F) After transfection with miR-637 mimic in HKF cells, the expression of MMP2 was detected by western blotting and qPCR. Data are presented as mean ± SEM. **P<0.01 vs. control. (G and H) After downregulation of miR-637, the expression of MMP2 was detected by western blotting and qPCR. Data are presented as mean ± SEM. **P<0.01 vs. control. miRNA, microRNA; qPCR, quantitative polymerase chain reaction; SEM, standard error of the mean; SD, standard deviation; HKF, human keloid fibroblast; MMP, matrix metallopeptidase.