Fig. 3.

Selection of hippocampal responses to sound in the absence of a task. (A) Bilateral LFP responses in rabbit hippocampus to a whistle. Adapted from Green, J.D., Arduini, A.A., 1954. Hippocampal electrical activity in arousal. J. Neurophysiol. 17, 533–557. Green and Arduini (1954). (B) Left: Postsynaptic CA1 interneurons expressing tdTomato (red) and septo-hippocampal GABA axons expressing GCaMP5 (green) in mouse hippocampus with six labelled boutons. Right: Stimulus-triggered Ca²⁺ averages (+/- SEM) at the same six boutons in response to air-puffs or a 20-s 10-kHz tone. Scale bars show 50% ΔF/F and 3 s. Adapted by permission from Springer Nature Customer Service Centre GmbH: Springer. Nature Neuroscience. Septo-hippocampal GABAergic signaling across multiple modalities in awake mice. Kaifosh, P., Lovett-Barron, M., Turi, G.F., Reardon, T.R., Losonczy, A., 2013. Nat. Neurosci. 16, 1182-1184. Copyright © 2013 Nature America, Inc. Kaifosh et al. (2013). (C) Intervals between firing rate peaks in 338 CA1 cells in 5 mice during 40 Hz click stimulation (blue), random-interval click stimulation (orange) and no stimulation (gray). Reprinted from Cell, 177, Martorell, A.J., Paulson, A.L., Suk, H.-J., Abdurrob, F., Drummond, G.T., Guan, W., Young, J.Z., Kim, D.N.-W., Kritskiy, O., Barker, S.J., Mangena, V., Prince, S.M., Brown, E.N., Chung, K., Boyden, E.S., Singer, A.C., Tsai, L.-H, Multi-sensory gamma stimulation ameliorates Alzheimer’s-associated pathology and improves cognition, 256-271, Copyright © 2019 Elsevier Inc., with permission from Elsevier. Martorell et al. (2019). (D) Similar-latency LFP responses in cat ventral hippocampus and auditory cortex. Responses to two successive clicks separated by 15 s are shown side by side. Reprinted from Electroencephalography and Clinical Neurophysiology, 8, Green, J.D., Adey, W.R., Electrophysiological studies of hippocampal connections and excitability, 245-262, Copyright © 1956 Published by Elsevier Ireland Ltd., with permission from Elsevier. Green and Adey (1956). (E) Spike rasters for a single cell in bat CA1 show selective responses to frequency sweeps of 1-ms duration (left) but not 5-ms duration (right) duration presented at 0 ms. Adapted with permission from Yu, C., Moss, C.F., 2022. Natural acoustic stimuli evoke selective responses in the hippocampus of passive listening bats. Hippocampus 32, 298-309. Copyright © 2022 The Authors. Hippocampus published by Wiley Periodicals LLC. Yu and Moss (2022). (F) Mean firing rate (+/- SEM) of single cell in monkey hippocampus in response to voices and other sounds. Adapted from Sliwa, J., Planté, A., Duhamel, J.-R., Wirth, S. Independent neuronal representation of facial and vocal identity in the monkey hippocampus and inferotemporal cortex. Cerebral Cortex, 2014, 26, 950-966, by permission of Oxford University Press. Sliwa et al. (2014). (G) Spike trains of rabbit CA3 neurons. Top: Activatory response at Unit A to 5th presentation of a 900 Hz tone. Middle/Bottom: Responses at Unit B to 5th and 8th presentations of an 800 Hz tone, showing suppression that habituates over trials. After Vinogradova (1975a). (H) Grand average evoked LFP response from CA3 in 12 rat hippocampi to pairs of clicks presented 500 ms apart. Reprinted from Biological Psychiatry, 27, Bickford-Wimer, P.C., Nagomoto, H., Johnson, R., Adler, L.E., Egan, M., Rose, G.M., Freedman, R., Auditory sensory gating in hippocampal neurons: A model system in the rat, 183-192, Copyright © 1990 Published by Elsevier Inc., with permission from Elsevier. Bickford-Wimer et al. (1990). (I) Grand average evoked response recorded intracranially in 21 human posterior hippocampi to clicks presented at 0 and 500 ms (dashed lines). Adapted with permission from Boutros, N.N., Mears, R., Pflieger, M.E., Moxon, K.A., Ludowig, E., Rosburg, T. Sensory gating in the human hippocampal and rhinal regions: Regional differences. Hippocampus 18, 310-316. Copyright © 2007 Wiley-Liss, Inc. Boutros et al. (2008).