Comparison 1. PUFA versus Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Seizure freedom	1	70	Risk Ratio (M‐H, Fixed, 95% CI)	20.0 [2.84, 140.99]
2 50% reduction in seizures frequency (12 weeks) ‐ Per protocol data	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Older (19 years of more)	2	78	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.19, 1.75]
2.2 Younger (< 19 years)	1	70	Risk Ratio (M‐H, Random, 95% CI)	33.0 [4.77, 228.15]
3 50% reduction in seizure frequency (12 weeks) ‐ Worst case scenario ‐ ITT	2	85	Risk Ratio (M‐H, Random, 95% CI)	0.29 [0.03, 2.63]
4 50% reduction in seizures frequency (12 weeks) ‐ Best case scenario ‐ ITT	2	85	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.24, 2.01]
5 50% reduction in seizures frequency (6 weeks)	1	58	Risk Ratio (M‐H, Fixed, 95% CI)	4.67 [0.58, 37.52]
6 Seizures frequency 12 weeks double‐blind	1	56	Mean Difference (IV, Fixed, 95% CI)	3.35 [‐26.45, 33.15]
7 Gastrointestinal effects	2	85	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.32, 1.89]