Table 3.
Predictive value of LDL-C and RC (categorical variables) for 5-year outcomes in multivariate Cox analysis
| Variables, mmol/L | Bleeding events |
ICH |
||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| LDL-C | ||||
| Model 1a | ||||
| Q1 | Reference | NA | Reference | NA |
| Q2 | 0.90 (0.69–1.18) | 0.457 | 1.35 (0.57–3.21) | 0.494 |
| Q3 | 0.79 (0.60–1.04) | 0.089 | 0.93 (0.36–2.40) | 0.872 |
| Q4 | 0.95 (0.73–1.24) | 0.715 | 1.56 (0.66–3.67) | 0.308 |
| Model 2b | ||||
| Q1 | Reference | NA | Reference | NA |
| Q2 | 0.92 (0.70–1.19) | 0.506 | 1.26 (0.53–3.01) | 0.599 |
| Q3 | 0.80 (0.60–1.06) | 0.113 | 0.87 (0.33–2.27) | 0.770 |
| Q4 | 0.98 (0.75–1.30) | 0.898 | 1.38 (0.57–3.30) | 0.473 |
| Model 3c | ||||
| Q1 | Reference | NA | Reference | NA |
| Q2 | 0.92 (0.70–1.20) | 0.518 | 1.27 (0.53–3.02) | 0.594 |
| Q3 | 0.80 (0.60–1.06) | 0.116 | 0.87 (0.33–2.27) | 0.771 |
| Q4 | 0.98 (0.75–1.30) | 0.905 | 1.38 (0.57–3.30) | 0.476 |
| Model 4d | ||||
| Q1 | Reference | NA | Reference | NA |
| Q2 | 0.91 (0.70–1.19) | 0.506 | 1.27 (0.53–3.02) | 0.594 |
| Q3 | 0.80 (0.60–1.06) | 0.113 | 0.87 (0.33–2.27) | 0.772 |
| Q4 | 0.98 (0.75–1.29) | 0.899 | 1.38 (0.58–3.31) | 0.472 |
| RC | ||||
| Model 1a | ||||
| Q1 | Reference | NA | Reference | NA |
| Q2 | 0.80 (0.61–1.03) | 0.081 | 1.02 (0.50–2.06) | 0.964 |
| Q3 | 0.79 (0.61–1.02) | 0.075 | 0.22 (0.06–0.76) | 0.017 |
| Q4 | 0.67 (0.51–0.89) | 0.006 | 0.66 (0.28–1.58) | 0.351 |
| Model 2b | ||||
| Q1 | Reference | NA | Reference | NA |
| Q2 | 0.80 (0.62–1.04) | 0.101 | 1.07 (0.52–2.21) | 0.850 |
| Q3 | 0.79 (0.59–1.05) | 0.102 | 0.23 (0.06–0.80) | 0.022 |
| Q4 | 0.66 (0.45–0.97) | 0.034 | 0.53 (0.17–1.65) | 0.274 |
| Model 3c | ||||
| Q1 | Reference | NA | Reference | NA |
| Q2 | 0.80 (0.61–1.04) | 0.098 | 1.08 (0.52–2.23) | 0.845 |
| Q3 | 0.79 (0.59–1.05) | 0.105 | 0.23 (0.06–0.81) | 0.022 |
| Q4 | 0.66 (0.45–0.97) | 0.035 | 0.53 (0.17–1.66) | 0.279 |
| Model 4d | ||||
| Q1 | Reference | NA | Reference | NA |
| Q2 | 0.80 (0.61–1.04) | 0.099 | 1.07 (0.52–2.22) | 0.852 |
| Q3 | 0.79 (0.59–1.05) | 0.100 | 0.23 (0.06–0.80) | 0.022 |
| Q4 | 0.66 (0.44–0.97) | 0.033 | 0.53 (0.17–1.65) | 0.273 |
RC, remnant cholesterol; LDL-C, low-density lipoprotein cholesterol; ICH, intracranial hemorrhage; HR, hazard ratio; CI, confidence interval; NA, not applicable.
The Q1, Q2, Q3, and Q4 of LDL-C were <1.88, 1.88–2.38, 2.39–3.0 and >3.0 mmol/L, respectively. The Q1, Q2, Q3, and Q4 of RC were <0.45, 0.45–0.61, 0.62–0.80 and >0.80 mmol/L, respectively.
Model 1 was adjusted for age, sex, and body mass index.
Model 2 was adjusted for Model 1 + hypertension, previous bleeding, previous stroke, femoral artery approach, hemoglobin, eGFR, duration of DAPT, HDL-C, and TG, because of their statistical significances (p < 0.05) in univariate analysis.
Model 3 was adjusted for Model 2 + high PRECISE-DAPT score.
Model 4 was adjusted for Model 2 + ARC-HBR criteria.