Table 1.
Comparison of Wound Healing and Patient Characteristics by Study Grouping
| Group A − healthier group + standard wound care (2019+2020) (n=32) |
Group B − suboptimal group + standard wound care (2019) (n=25) |
Group C − suboptimal group + standard wound care + topical timolol (2020) (n=18) |
||
|---|---|---|---|---|
| Age, Mean (standard deviation) | 64.3 (5.1) | 78.4 (6.4) | 75.3 (5.6) | |
| Average Post-op Wound Size, mm2 (SD) | 174† (93) | 172† (50) | 259† (129) | |
| Wound Thickness | Partial | 25 (78.1%) | 21 (84%) | 13 (72.2%) |
| Full | 7 (21.9%) | 4 (16%) | 5 (27.8%) | |
| Time to Re-Epithelization, weeks (SD) | 7.7‡ (2.0) | 10.8‡ (4.2) | 7.9‡ (3.0) | |
| Clinical Characteristics, No. (%) | ||||
| Atrophic skin | 3 (9.4%) | 12 (48%) | 12 (66.7%) | |
| Varicose veins | 4 (12.5%) | 13 (52%) | 5 (27.8%) | |
| Edematous lower extremities§ | 3 (9.4%) | 16 (64%) | 10 (55.6%) | |
| Stasis dermatitis/ changes§ | 1 (3.1%) | 3 (12%) | 7 (38.9%) | |
| Comorbidities, No. (%) | ||||
| Current/Former smoker | 6 (18.8%) | 7 (28%) | 5 (27.8%) | |
| Diabetes mellitus | 1 (3.1%) | 4 (16%) | 1 (5.6%) | |
| Hypertension / heart disease§ | 7 (21.9%) | 20 (80%) | 12 (66.7%) | |
| Immuno-suppression | 2 (6.3%) | 1 (4%) | 0 (0%) | |
| Deep vein thrombosis history | 0 (0%) | 1 (4%) | 1 (5.6%) | |
†
P-value* for the difference in means of groups A and B = 0.910; groups B and C = 0.004; groups A and C = 0.010.
‡
P-value* for the difference in means of groups A and B = 0.001; groups B and C = 0.012; groups A and C = 0.773
§
Statistically significant difference in characteristic 104 found across groups via Chi-squared analysis.