Figure 3.

(A) Summary of radioligand binding affinity studies; error values represent the standard deviation. (B) Plotted inhibition of binding for human CB₁ cannabinoid receptor in transfected Chem-1 cell lysate after treatment with 1, 4a, and 4b. (C) Plotted inhibition of binding for human CB₂ cannabinoid receptor in transfected CHO cell lysate after treatment with 1, 4a, and 4b. For all experiments, data represent two replicate experiments, with error bars showing standard deviation (error bars omitted for clarity if the range is smaller than the data symbol), and the Y-intercept was constrained to zero, unless otherwise noted (see the SI for details).