Table 2.
Mean difference within-group and between-group during treatment intervals (ITT)
| Test of within-group effects (mean change from baseline) | Test of between-group effects (mean change control group) | |||||
|---|---|---|---|---|---|---|
| Larvae, n = 15 | Conventional, n = 16 | Larvae vs conventional | ||||
| Outcomes | Mean [95% CI] | Mean [95% CI] | MD | 95% CI | P v | Cohen’s d [95% CI] |
| Necrosis (%) | ||||||
| Baseline to day 2 | − 0.27 [− 0.38, − 0.15]*** | − 0.12 [− 0.18, − 0.16]*** | − 0.14 | [− 0.28, − 0.01] | 0.028 | 0.91 [0.54, 1.27] |
| Baseline to day 4 | − 0.37 [− 0.49, − 0.25]*** | − 0.21 [− 0.28, − 0.15]*** | − 0.15 | [− 0.28, 0.02] | 0.023 | 0.73 [0.37, 1.08] |
| Baseline to day 6 | − 0.39 [− 0.51, − 0.27]*** | − 0.34 [− 0.40, − 0.28]*** | − 0.05 | [− 0.18, 0.08] | 0.45 | 0.38 [− 0.12, 0.88] |
| Granulation (%) | ||||||
| Baseline to day 2 | 0.30 [0.21, 0.39]*** | 0.11 [0.03, 0.19]*** | 0.18 | [0.06, 0.31] | 0.003 | 1.05 [0.68, 1.42] |
| Baseline to day 4 | 0.49 [0.39, 0.59]*** | 0.24 [0.16, 0.33]*** | 0.24 | [0.11, 0.37] | < 0.001 | 1.06 [0.69, 1.43] |
| Baseline to day 6 | 0.60 [0.51, 0.70]*** | 0.34 [0.25, 0.43]*** | 0.26 | [0.13, 0.38] | < 0.001 | 1.20 [− 0.12, 0.88] |
| Granulation/necrosis | ||||||
| Baseline to day 2 | 5.01 [0.08, 9.94]* | 0.23 [− 0.47, 0.94] | 4.77 | [− 0.22, 9.77] | 0.06 | 0.48 [− 0.08, 1.04] |
| Baseline to day 4 | 15.5 [10.6, 20.5]*** | 0.81 [0.10, 1.52]* | 14.7 | [9.74, 19.73] | < 0.001 | 1.37 [0.58, 2.13] |
| Baseline to day 6 | 13.7 [8.8, 18.6]*** | 1.43 [0.70, 2.16]*** | 12.32 | [7.28, 17.37] | < 0.001 | 2.72 [1.72, 3.70] |
*P < 0.05
***P < 0.001
aAdjusted generalized estimating equations model after controlling the baseline outcome, wound size (cm2)