Table 1.
Population characteristics of the HIV-positive VACS-BC participants with genotype-derived AFR ancestry
| Characteristic | 450K (N = 423) | EPIC (N = 388) | Pvalues for comparison between 450K and EPIC** | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Cocaine user (N = 165) | Controls (N = 258) | Overall | Pvalue* | Cocaine user (N = 128) | Controls (N = 260) | Overall | Pvalue* | ||
| HIV-positive (%) | 165 (100%) | 258 (100%) | 423 (100%) | 1.0000 | 128 (100%) | 260 (100%) | 388 (100%) | 1.0000 | 1.0000 |
| Genotype derived ancestry-AFR (%) | 165 (100%) | 258 (100%) | 423 (100%) | 1.0000 | 128 (100%) | 260 (100%) | 388 (100%) | 1.0000 | 1.0000 |
| Sex-male (%) | 165 (100%) | 258 (100%) | 423 (100%) | 1.0000 | 128 (100%) | 260 (100%) | 388 (100%) | 1.0000 | 1.0000 |
| Age | 49.2 ± 6.13 | 49.4 ± 8.19 | 49.3 ± 7.45 | 0.7785 | 48.2 ± 5.99 | 47.8 ± 8.88 | 47.9 ± 8.04 | 0.6229 | 0.0108 |
| log10 viral load | 2.70 ± 1.51 | 2.43 ± 1.28 | 2.54 ± 1.38 | 0.0591 | 2.66 ± 1.52 | 2.50 ± 1.22 | 2.56 ± 1.33 | 0.2975 | 0.8413 |
| Antiviral medication adherence (%) | 120 (73.6%) | 204 (81.3%) | 324 (76.6%) | 0.0849 | 82 (66.7%) | 208 (80.6%) | 290 (74.7%) | 0.0043 | 0.5941 |
| Cigarette smoking (%) | 132 (81.5%) | 119 (46.7%) | 251 (59.3%) | 3.03E-12 | 99 (81.8%) | 111 (42.8%) | 210 (54.1%) | 2.47E-12 | 0.1537 |
| Alcohol use (%) | 86 (52.4%) | 94 (37.9%) | 180 (42.6%) | 0.0050 | 66 (53.6%) | 76 (31.5%) | 142(36.6%) | 6.91E-05 | 0.0970 |
Mean ± SD for continuous variables and n (%) for categorical variables
* Pvalues were reported for the comparison between cocaine users and non-users (controls)
** Pvalues were reported for the comparison between overall 450K samples and overall EPIC samples