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. 2023 Sep 19;21:196. doi: 10.1186/s12915-023-01698-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Detection and profile of lysine lactylation in mice iWAT. A Schematic representation of the experimental workflow for 4D label-free lactylation quantitative proteomics in CON, HIIT, and DCA + HIIT mice. B Distribution of the number of differentially lactylated lysine sites and proteins. C Pie chart of the predicted subcellular localization of lysine lactylated proteins. D Distribution of the number of lysine lactylation sites per protein that were significantly upregulated (fold change > 1.3, p < 0.05) and downregulated (fold change < 0.7, p < 0.05) among groups. Distribution of the number (E), hierarchical clustering and heatmap analysis (G), and KEGG pathway analysis (H) of lysine lactylation sites per protein that were upregulated in HIIT mice and downregulated in DCA + HIIT mice. F Lysine lactylation sites of FASN; n = 3. KEGG Kyoto Encyclopedia of Genes and Genomes, HIIT high-intensity interval training, DCA + HIIT dichloroacetate injection + high-intensity interval training