Skip to main content
. 2023 Sep 19;14:257. doi: 10.1186/s13287-023-03490-6

Fig. 7.

Fig. 7

Schema indicates that UCMSC-derived ApoEVs, after being phagocytosed by macrophages, exert their anti-inflammation efficacy by relieving oxidative stress status, reducing the production and assembly of the inflammasome NLRP3, and then inhibiting macrophage pyroptosis, thus provide a promising therapy for delayed cutaneous wound healing of T2DM. ROS reactive oxygen species; CAT catalase; GSH glutathione; SOD superoxide dismutase; MDA malondialdehyde; IL-1β interleukin-1 beta; IL-18 interleukin-18; CASP1 caspase-1; GSDMD gasdermin D