Table 2.
Levels of Hemostatic Parameters.
| 25(OH)D ≤ 50 nmol/L | 25(OH)D ≥ 100 nmol/L | P-value1 | Adjusted P-value2 | |
|---|---|---|---|---|
| vWF [%] | 151 ± 47 | 170 ± 48 | .018 | .148 |
| Thrombin generation | ||||
| Lag time [min] | 2.69 ± 0.41 | 2.81 ± 0.39 | .079 | .022 |
| ETP [nmol/L x min] | 2303 ± 353 | 2395 ± 464 | .292 | .011 |
| Peak [nmol/L] | 409 ± 54.5 | 423 ± 66.4 | .248 | .017 |
| ttpeak [min] | 5.28 ± 0.60 | 5.44 ± 0.58 | .109 | .058 |
| Start tail [min] | 24.0 ± 1.83 | 23.9 ± 1.97 | .814 | .349 |
| Factor VIII [%] | 114 ± 35 | 121 ± 32 | .115 | .291 |
| PAI-1 [ng/mL] | 16.8 ± 7.0 | 13.5 ± 7.6 | .006 | .007 |
| PAI-2 [ng/mL] | 15.9 ± 6.8 | 19.0 ± 8.9 | .009 | .222 |
| PAI-1/PAI-2 ratio | 1.22 ± 0.66 | 0.75 ± 0.39 | <.001 | <.001 |
| tPA [mg/mL] | 3.96 ± 1.62 | 4.10 ± 1.65 | .629 | .421 |
| Fibrinogen [µmol/L] | 12.3 ± 2.08 | 12.4 ± 1.98 | .674 | .124 |
| D-dimer [mg/L FEU] | 1.30 ± 3.78 | 0.85 ± 2.44 | .273 | .375 |
| CRP [mg/l] | 5.08 ± 4.51 | 5.21 ± 5.88 | .509 | .294 |
Levels of the hemostatic parameters in the group of vitamin D deficient pregnant women (serum vitamin D levels ≤50 nmol/L) compared to the group of pregnant women with high adequate vitamin D status (serum vitamin D levels ≥100 nmol/L). Data are presented as mean ± SD. P-values are indicated for primary comparison1 (student's t test or Mann–Whitney test) and for multiple regression2 separately. P-values <0.05 are highlighted in bold. Multiple regression models were adjusted for pre-pregnancy, BMI, smoking status, and use of fish oil supplements. Abbreviations: 25(OH)D, 25-hydroxy vitamin D; BMI, body mass index; CRP, c-reactive protein; FEU, fibrinogen equivalent units; PAI-1, plasminogen activator inhibitor 1; PAI-2, plasminogen activator inhibitor 2; tPA, tissue plasminogen activator; vWF, von Willebrand factor; ttpeak, time to peak; ETP, endogenous thrombin potential.