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Clinical-stage inhibitors of Mpro and a panel of initial peptidomimetic inhibitors. (A) Covalent inhibitors of Mpro that are clinically used or underwent clinical evaluation. (B) General design of a panel of peptidomimetic inhibitors featuring various electrophilic warheads, including α,β-unsaturated ester, vinylsulfone, vinylsulfonamide, terminal alkyne, aldehyde, ketoamide, and nitrile.
