Scheme 6. Synthesis of Anilinoquinazoline Acrylamide.
Reagents and conditions: (i) (a) (COCl)2, DMF, THF, rt, 1 h, (b) (E)-3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acrylic acid, 58, pyridine, THF, rt, 12 h.
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