. 2023 Sep 5;66(17):12203–12224. doi: 10.1021/acs.jmedchem.3c00795

Table 7. In Vivo Pharmacokinetic Properties of Selected Compounds in Rats (0.3 mg/kg iv bolus and 1.0 mg/kg po).

compd	AUC_norm^iv [kg·h/L]	CL [L/h/kg]	V_ss [L/kg]	MRT_iv [h]	AUC_norm^po [kg·h/L]	F^a [%]	f_u [%]
compd	AUC_norm^iv [kg·h/L]	CL [L/h/kg]	V_ss [L/kg]	MRT_iv [h]	AUC_norm^po [kg·h/L]	F^a [%]	rat/human/rabbit
25	1.3	0.79	1.1	2.1	0.87	67	9.1/4.5/8.6
34	1.0	0.98	1.8	1.9	0.53	53	15/5.2/14
71	1.5	0.67	0.98	1.5	0.67	42	n.d.^b
75	n.d.	n.d.	n.d.	n.d.	0.46	n.d.	n.d.
76	n.d.	n.d.	n.d.	n.d.	0.45	n.d.	n.d.
77	n.d.	n.d.	n.d.	n.d.	0.84	n.d.	n.d.
78	2.0	0.51	0.83	1.6	1.1	53	2.2/7.0/16
79	n.d.	n.d.	n.d.	n.d.	1.3	n.d.	n.d.
80	2.2	0.46	0.76	2.5	1.3	60	2.4/6.4/14
81	1.7	0.58	1.0	1.8	0.56	33	n.d.
82	1.2	0.83	1.5	1.8	0.72	60	n.d.
83	2.2	0.45	1.4	3.1	0.87	40	n.d.

Oral bioavailability.

n.d.: not determined.