. 2023 Sep 5;66(17):12203–12224. doi: 10.1021/acs.jmedchem.3c00795

Table 8. In Vivo Pharmacokinetic Properties of Selected Compounds in Dogs (0.3 mg/kg iv infusion and 1.0 mg/kg po).

compd	AUC_norm^iv [kg·h/L]	CL [L/h/kg]	V_ss [L/kg]	MRT_iv [h]	AUC_norm^po [kg·h/L]	F^a [%]	f_u [%]
compd	AUC_norm^iv [kg·h/L]	CL [L/h/kg]	V_ss [L/kg]	MRT_iv [h]	AUC_norm^po [kg·h/L]	F^a [%]	dog
25	7.7	0.13	0.55	4.2	3.9	51	8.5
34	2.1	0.48	1.40	2.9	1.9	55	13
80	5.3	0.19	1.80	9.4	5.1	97	10