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. Author manuscript; available in PMC: 2024 Jun 15.
Published in final edited form as: Cell Chem Biol. 2023 Apr 28;30(6):683–698.e3. doi: 10.1016/j.chembiol.2023.04.004

Figure 6. Cysteines with available functional and structural annotations.

Figure 6.

(A) CysDB-identified, ligandable, and hyperreactive proteins with annotated active sites, binding sites, catalytic activity, disulfide bonds, and redox potentials.

(B) Distribution of identified cysteines in CysDB ID annotated as cysteine-specific binding sites or active sites (left). The total number of cysteines in UniProtKB annotated as binding or active sites are shown in gray. Percentage of proteins associated with a PDB structure and containing an identified cysteine.

(C) Percentage of proteins associated with a PDB structure and containing a ligandable (CysDB LIG) or hyperreactive (CysDB HYPERREACTIVE) cysteine.

(D) Top 10 enriched protein domains from Pfam term enrichment analysis of liganded (green) and hyperreactive (light blue) proteins.

(E) Top 10 enriched pathways from Panther term enrichment analysis of liganded (green) and hyperreactive (light blue) proteins.

See also Figures S11–S20 and Data S3.