FIGURE 3.

Structural similarity comparison between predicted models and PDB experimental structures using TM‐score. Shown are overlaid structures of the predicted model (p‐RBD) and the reported experimental structures of (a) closed‐state RBD (from PDB 6VXX) and (b) open‐state RBD (from PDB 6VYB). (c) Columns show the mean value of TM‐score and error bar shows the standard deviation. The influence of enabling Amber force field (Amber FF) on model prediction was also considered and no significant difference was found between models with and without the Amber FF. RBD, receptor‐binding domain.