Table 3. Receptor Binding Affinities and Enzyme Inhibition for 9i and 7.

		9i			7
receptor/enzyme	ligand	IC50 (μM)	Ki (μM)	nH	IC50 (μM)	Ki (μM)	nH
5-HT1A	1.50 nM [3H] 8-OH-DPAT	0.19	0.11	1.26	0.18	0.10	0.97
5-HT1B	1.0 nM [3H] GR125743	1.99	1.52	0.74	2.42	1.84	0.76
5-HT2A	0.5 nM [3H] ketanserin	0.22	0.06	0.84	0.15	0.04	0.78
5-HT2B	2.0 nM [3H] mesulergine	0.41	0.30	0.98	0.48	0.35	1.08
5-HT2C	1.0 nM [3H] mesulergine	0.39	0.20	0.94	0.53	0.28	1.38
5-HT5A	1.70 nM [3H] lysergic acid diethylamide (LSD)	3.32	1.71	1.01	3.32	1.71	0.91
5-HT6	1.50 nM [3H] lysergic acid diethylamide (LSD)	1.08	0.50	0.77	1.21	0.56	0.84
5-HT7	5.50 nM [3H] lysergic acid diethylamide (LSD)	0.09	0.05	0.67	0.12	0.07	0.91
α1A	0.6 nM [3H] prazosin	0.99	0.48	1.00	0.58	0.28	0.75
α1B	0.2 nM [3H] prazosin	0.93	0.37	0.94	0.67	0.26	0.94
α1D	0.6 nM [3H] prazosin	3.26	1.60	0.73	3.07	1.51	0.85
α2A	1.50 nM [3H] rauwolscine	3.03	1.52	1.00	2.22	1.11	0.76
α2B	2.50 nM [3H] rauwolscine	1.67	0.76	0.97	1.58	0.72	1.09
α2C	0.5 nM [3H] rauwolscine	6.10	2.71	1.03	9.47	4.21	0.56
H1	1.20 nM [3H] pyrilamine	0.34	0.16	0.63	0.52	0.25	1.09
I2, central	2.0 nM [3H] idazoxan	2.60	1.73	0.99	1.93	1.29	0.87
nAChα3β4	0.05 nM [125I] epibatidine	4.40	3.18	0.90	4.20	3.03	0.79
MAO-A		1.50			1.18