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. 2023 Aug 30;17(17):16432–16447. doi: 10.1021/acsnano.2c12857

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© 2023 The Authors. Published by American Chemical Society

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Therapeutic effect of Ang/TAT-sgGSS-EVs on patient-derived GSC xenografts. (A) Schematic of patient-derived xenograft (PDX)–derived GSC orthotopic model establishment. (B) GSS and LRP-1 protein expression in LN229, GSC05 and NHA, respectively. (C) Luminescence images of orthotopic GSC05-Luc GSC tumor–bearing mice following treatment. (D) Tumor growth and volume quantification. Survival curves of LN229-bearing mice. n = 8 animals per treatment group. (E) IHC analysis of GSS and 4-HNE expression in tumor tissues. (F) Relative level of MDA and GSH. (H) Indel frequency of GSS gene in tumor tissues excised from mice on day 28. (I) Sequencing results of GSS gene editing in GSC05-bearing mice treated with Ang/TAT-sgGSS-EVs.