Scheme 4. The preparation of saturated analogues of MGL inhibitor 7 and fendizoic acid (9) and derivatization of selected bicyclo[2.1.1]hexanes. Reagents and conditions: (a) Me₂NH (2 equiv), iPrMgCl (3.5 equiv), THF, −5 °C → RT, 2 h, 95%; (b) NaH (2 equiv), MeI (2 equiv), THF, RT, 4 days, 33%; (c) PhLi (3 equiv), THF, 0 °C, 45 min, 78%; (d) LiAlH₄ (2.1 equiv), Et₂O, 0 °C → RT, overnight, 26%; (e) Ac₂O (5 equiv), Et₃N (5 equiv), DMAP (0.5 equiv), CH₂Cl₂, RT, overnight, 96%; (f) NaOH (3.2 equiv), EtOH : H₂O (4 : 1), RT, overnight, 75%.