Table I.
Tissue | Phenotypes | Strain and target | Refs |
---|---|---|---|
Liver | Hepatic lipid accumulation under a high fat diet. Enhanced fasting hyperglycemia and hyperinsulinemia. | C57BL/6J Deletion of Exon 2 |
Hinds et al. |
Whole body | Enhanced endogenous oxidative stress: higher concentrations of cholesteryl ester hydroperoxides and oxidized peroxiredoxin 2. | C57BL/6J Deletion of Exon 3 |
Chen et al. |
Whole body | Enhanced sensitivity to oxidative stress in neurons. | C57BL/6J Deletion of Exon 3 |
Vasavda et al. |
Myeloid cells | Enhanced chemokine expression and chemotaxis in myeloid cells. | 129S/C57BL/6J Deletion of exons 4 and 5 |
Bisht et al. |