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Schematic illustrating the mechanisms whereby ethanol inhibits autophagy and thus sensitizes pancreas to pancreatitis induced by stressors such as supramaximal CER/CCK. Dashed line indicates ethanol’s effects not explored in this study but characterized in detail by us and other groups (5, 8, 9, 12, 14,15, 23, 33, 37, 51). CCK, cholecystokinin-8; CER, cerulein.
