Table 2.

Water consumption and urinary electrolyte and osmol excretion in normal-salt diet-fed (day −3 to day −1) Dahl salt-sensitive rats (vehicle- vs. ranitidine-treated groups)

	Vehicle						Ranitidine
	Day −3		Day −2		Day −1		Day −3		Day −2		Day −1
	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE
24-h water consumption, mL	13.4*	1.9	14	1	14.3	1	11.7*	0.5	13.7	0.6	13.2	0.6
24-h Na+ excretion, µmol	625	92	798	83.3	852	54.2	882	141.9	668	69.9	718	70.5
24-h Cl− excretion, µmol	728*	101.6	1,026	82.3	1,100	59.3	1,108*	131.7	930	57.3	1,131	73.9
24-h K+ excretion, µmol	1,498	549.1	1,375	350.4	1,515	352.4	1,634	409.3	1,231	221.8	1,294	86.1
8-h osmol excretion, mmol	2.1	0.4	3.1	0.3	3	0.2	3.2	0.4	2.7	0.2	2.7	0.2
8-h urine pH, mmol	5.3	0.1	5.3	0.1	5.4	0.04	5.4	0.04	5.8	0.4	5.9	0.4

n = 7 for vehicle treatment and 10 for ranitidine treatment. The following parameters were assessed: water consumption, urinary Na⁺ excretion, urinary Cl⁻ excretion, and urinary K⁺ excretion for the 24-h period as well as 8-h osmol excretion and urine pH levels. *Statistical significance (P < 0.05) for vehicle vs. ranitidine treatment. Repeated-measures ANOVA with a Holm-Sidak post hoc test was used for statistical analysis.