Table 3.
Water consumption and urinary electrolyte and osmol excretion in high-salt diet-fed (days 21−23) Dahl salt-sensitve rats (vehicle- vs. ranitidine-treated groups)
| Vehicle |
Ranitidine |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Day 21
|
Day 22
|
Day 23
|
Day 21
|
Day 22
|
Day 23
|
|||||||
| Mean | SE | Mean | SE | Mean | SE | Mean | SE | Mean | SE | Mean | SE | |
| 24-h water consumption, mL | 32.4 | 2 | 33.5 | 2.8 | 35.1 | 3.1 | 32.2 | 1.4 | 30.6 | 1.3 | 30.3 | 1.2 |
| 24-h Na+ excretion, µmol | 8,655 | 758.1 | 7,774 | 842.3 | 5,996 | 982.4 | 8,330 | 553.3 | 8,372 | 629 | 6,131 | 1,087.3 |
| 24-h Cl− excretion, µmol | 9,187 | 735.8 | 8,418 | 754.9 | 6,674 | 1,037.1 | 8,776 | 688 | 9,458 | 451.8 | 7,177 | 1,224.3 |
| 24-h K+ excretion, µmol | 1,919 | 130.7 | 1,557 | 142.8 | 1,196 | 159.6 | 1,744 | 138.6 | 1,757 | 63 | 1,336 | 200.1 |
| 8-h osmol excretion, mmol | 3.9 | 0.4 | 4.5 | 0.6 | 3.8 | 0.6 | 4.1 | 0.4 | 4 | 0.8 | 3.8 | 0.4 |
| 8-h urine pH, mmol | 6 | 0.3 | 6.9 | 0.5 | 6.4 | 0.5 | 6.1 | 0.4 | 6.6 | 0.4 | 6.5 | 0.5 |
n = 7 for vehicle treatment and 10 for ranitidine treatment. The following parameters were assessed: water consumption, urinary Na+ excretion, urinary Cl− excretion, and urinary K+ excretion for the 24-h period as well as 8-h osmol excretion and urine pH levels. Repeated-measures ANOVA with a Holm-Sidak post hoc test was used for statistical analysis.