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. 2020 May 15;36(2):173–177. doi: 10.5146/tjpath.2018.01446

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Copyright © 2020 The Author(s).

This is an open-access article published by Federation of Turkish Pathology Societies under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.

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A) Low magnification shows core biopsy with proliferation of bland spindle cells (H&E; x20). B-D) High magnification shows different areas observed in the biopsy such as areas with predominance of lymphoplasmacytic infiltrate and spindle cells arranged in long fascicles. (H&E; x40). E-F) IHC shows comparison of ALK immunostains, on both the Dako platform using monoclonal mouse anti-human CD246 antibody (clone ALK1) which showed focal positivity with weak intensity (F; x40) and the Ventana platform using monoclonal rabbit anti-human CD246 antibody (clone D5F3) reported as strong positive (E; x40). Spindle cells are negative for the following: G) Desmin H) CK I) CD117 and J) S-100 (IHC; x40). K) SMA positivity in neoplastic cells (IHC; x40).