Table 4.
Univariate and multivariate Cox regression analysis of clinical and dosimetric parameters associated with overall survival and non-cancer death.
| Endpoint | Overall survival HR (95% CI) | Non-cancer death HR (95% CI) | ||||
|---|---|---|---|---|---|---|
| Structure | UVA - HR (95% CI) | P value | MVA - HR (95% CI) | P value | UVA - HR (95% CI) | P value |
| Age | 1.01 (1.0–1.1) | 0.27 | 1.04 (1.0–1.1) | 0.04756 | 1.0 (0.95–1.1) | 0.5 |
| KPS | 1.04 (1.0–1.1) | 0.47 | – | – | 1.0 (0.98–1.1) | 0.5 |
| Sex Female Male |
Reference 1.2 |
- 0.82 |
– - |
– - |
- 1.8 (0.21–15) |
- 0.6 |
| Tumor size | 1.4 (1.2–1.7) | 0.005 | 1.37 (1.1–1.7) | 0.00457 | 1.5 (1–2.3) | 0.053 |
| PTV to heart distance | 1.04 (0.84–1.3) | 0.82 | 1.1 (0.84–1.3) | 0.653 | 0.75 (0.4–1.5) | 0.398 |
| Primary diagnosis NSCLC (primary and non-metastatic) OMD Polymetastatic disease |
Reference 0.5 (0.2––1.1) 5.2 (1.4–19.0) |
0.31 0.16 |
0.71 6.17 (1.5–25.4) |
0.41 0.01178 |
0.5 (0.09–3.2) 10.2 (1.8–128.0) |
0.49 0.07 |
| Cardiotoxic systemic therapy | 1.2 (0.5–2.8) | 0.82 | – | – | 0.69 (0.08–6.1) | 0.74 |
| Cardiovascular risk factor at baseline | 1.3 (0.6–3.0) | 0.82 | – | – | 1.2 (0.7–2-8) | 0.54 |
| Heart (D1cc) Heart (D0.5 cc) Heart (D0.1 cc) Heart (DMAX) Heart (DMEAN) |
1.0 (0.99–1) 1.0 (0.99–1) 1.0 (0.99–1) 1.0 (0.99–1) 1.1 (0.94–1.3) |
0.82 0.82 0.82 0.82 0.62 |
- - - - - |
- - - - - |
1.0 (0.98–1) 1.0 (0.98–1) 1.0 (0.98–1) 1.0 (0.98–1) 1.1 (0.79–1.6) |
0.83 0.82 0.73 0.68 0.54 |
| Left atrium (D0.1 cc) | 1.0 (1.0–1.0) | 0.62 | – | – | 1.0 (0.98–1) | 0.7 |
| Right atrium (D0.1 cc) | 0.99 (0.98–1.0) | 0.81 | – | – | 1.0 (0.97–1) | 0.91 |
| Right atrium (D45%) | 1.0 (0.9–1.1) | 0.97 | – | – | 0.87 (0.5–1.5) | 0.62 |
| Left ventricle (D0.1 cc) | 1.0 (1.0–1.0) | 0.31 | – | – | 0.99 (0.9–1.1) | 0.81 |
| Right ventricle (D0.1 cc) | 1.0 (0.97–1.0) | 0.82 | – | – | 1.0 (0.94–1.1) | 0.63 |
| Right ventricle (D45%) | 1.1 (0.79–1.6) | 0.82 | – | – | 1.1 (0.46–2.5) | 0.88 |
| Left coronary artery (D0.1 cc) | 1.1 (1.0–1.1) | 0.27 | 1.04 (0.98–1.1) | 0.16516 | 1.0 (0.92–1.2) | 0.49 |
| Left anterior descending artery (D0.1 cc) | 1.0 (0.98–1.1) | 0.49 | – | – | 1.1 (0.92–1.2) | 0.44 |
| Left circumflex artery (D0.1 cc) | 1.01 (1.0–1.1) | 0.16 | 1.02 (1.0–1.1) | 0.178 | 1 (0.92–1.1) | 0.98 |
| Right coronary artery (D0.1 cc) | 1.0 (0.95–1.1) | 0.82 | – | – | 1 (0.88–1.2) | 0.8 |
| Aortic valve (D0.1 cc) | 0.99 (0.96–1) | 0.82 | – | – | 0.99 (0.93–1.1) | 0.82 |
| Pulmonary valve (D0.1 cc) | 1.0 (0.99–1.1) | 0.31 | – | – | 1.1 (0.95–1.2) | 0.31 |
| Mitral valve (D0.1 cc) | 1.0 (1–1.1) | 0.31 | – | – | 0.99 (0.87–1.1) | 0.84 |
| Tricuspid valve (D0.1 cc) | 1.0 (0.99–1) | 0.86 | – | – | 0.9 (0.64–1.3) | 0.55 |
| Sinoatrial node (D0.1 cc) | 1.0 (0.98–1) | 0.97 | – | – | 1 (0.99–1.1) | 0.19 |
| Atrioventricular node (D0.1 cc) | 0.99 (0.96–1) | 0.82 | – | – | 0.98 (0.9–1.1) | 0.7 |
| Superior vena cava (D0.1 cc) | 1.0 (0.98–1) | 0.82 | – | – | 1 (0.97–1) | 0.99 |
| Superior vena cava (DMEAN) | 1.0 (0.97–1.0) | 0.82 | – | – | 1.01 (1–1.1) | 0.04 |
| Pulmonary artery (D0.1 cc) | 1.0 (0.99–1.0) | 0.31 | – | – | 1 (1–1) | 0.091 |
| Pulmonary artery (DMEAN) | 1.1 (1.0–1.1) | 0.26 | – | – | 1.20 (1.1–1.4) | 0.0026 |
| Aorta (D0.1 cc) | 1.0 (0.99–1) | 0.33 | – | – | 1 (0.99–1.1) | 0.15 |
Sex, primary diagnosis, cardiotoxic systemic therapy, cardiovascular risk factors were defined as categorical variables, while all other variables were defined as continuous. Correction for multiple testing was conducted using Benjamini-Hochberg procedure.