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. 2023 Aug 28;142(10):1461–1476. doi: 10.1007/s00439-023-02590-w

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© The Author(s) 2023

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Fig. 2 — A total of 33 genes that colocalized across body tissue, evaluated at the a single-cell and b bulk tissue level, were estimated to have their expression increase (red) and decrease (blue) risk of COVID-19 outcomes. In bulk tissue, COVID + referred to individuals who had tested positive for COVID-19 with COVID- for those who tested negative and Symptoms + refers to individuals who presented with symptoms of COVID-19 with Symptoms- referring to those who did not have symptoms of COVID-19. COVID- Symptom- refers to GTEx whole blood. Note that some transcripts show increased expression in some tissues to be associated with COVID-19 outcomes, whereas other tissues show decreased expression to be associated with the same transcript for the same outcome. TCM T central memory cell. TEM T effector memory cell. TN T naïve cell