Table 4.

Effect of T. erecta leaves fractions (ethyl acetate, butanol) & acacetin 7-O-glucoside on each of the following: inflammatory mediators

Inflammatory mediators	Group 1 Control	Group 2 Den [55 mg/kg]	Group 3 Den + DoX [10 mg/kg]	Group 4 Den + EB [50 mg/kg]	Group 5 Den + EE [50 mg/kg]	Group 6 Acacetin 7-O-glucoside [0.44 mg/ml]
IL-Iβ pg/ml	146 ± 1	204 ± 0.5*	139 ± 1	192 ± 1	186 ± 1	142 ± 3
Caspase-3 pg./ml	0.75 ± 0.3	3.9 ± 0.15*	1.15 ± 0.05	2.0 ± 0.1	2.4 ± 0.1	1.8 ± 0.1
Rat TNF-α ng/ml	38.5 ± 0.5	48.3 ± 1.3*	42.7 ± 0.9	56.6 ± 0.6	59 ± 0.6	43 ± 1

Data are represented as mean ± SEM (n = 6). *p < 0.05 vs. normal control, #p <0.05 vs Den, *#p < 0.05 vs Den + Dox. Statistical analysis was done using one-way ANOVA followed by the Dunnett test as a multiple comparison test. ALT, analine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; IL-Iβ, interleukin 1 beta; Caspase-3, cysteine-aspartic protease-3; Rat TNF-α, rat tumor necrosis factor-alpha; MDA, malondialdehyde; GSH, glutathione; Dox, doxorubicin; EB, erecta butanol; EE, erecta ethylactate. (* significant from -ve control &# significant from +ve control)