Table 8.
Effect of T. erecta leaves fractions (ethyl acetate, butanol) & acacetin 7-O-glucoside on each of the following: histopathological examination
| Group 1 Control | Group 2 Den [55 mg/kg] | Group 3 Den + DoX [10 mg/kg] | Group 4 Den + EB [50 mg/kg] | Group 5 Den + EE [50 mg/kg] | Group 6 Acacetin 7-O-glucoside [0.44 mg/ml] | |
|---|---|---|---|---|---|---|
| Score of liver fibrosis | 1.13 ± 0.2 | 9.86 ± 1.2* | 1.9460 ± 0.35 # | 4.34 ± 0.81*#^ | 4.3 ± 0.16*#^ | 1.08 ± 0.43# |
Histological assessment of percentage of tissue fibrosis in liver sections in the four examined treated groups (Den., diethylnitrosamine; dox, doxorubicin; EE, Thunbergia erecta ethyl acetate extract; EB, Thunbergia erecta butanol extract; and acacetin 7-O-glucopyranosid) (represent the mean ± SEM) showed a significantly higher value (p < 0.001) vs. the control (p < 0.001) vs Den. (* significant from -ve control &# significant from +ve control), (^) indicate significance from doxorubicin