Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 20;14:5830. doi: 10.1038/s41467-023-41418-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Macroscopic characteristics of representative involved ileal segments with attached hyperplastic CF from CD patients. b Haematoxylin and eosin- and Masson trichrome-stained ileal segments with attached CF. Scale bars, 500 μM. c Scanning electron microscopy examination of H-MAT, CD-MAT and CF. Scale bars, 50 μM. d Absolute number of nascent adipocytes (diameter < 10 μM) in H-MAT of control subjects (n = 8), CD-MAT and CF of CD patients (n = 14) counted in (c). The centre line represents the mean and p value were determined via two-sided one-way ANOVA. e Orthogonal partial least squares discriminant analysis (OPLS-DA) score plot of whole mesenteric adipose tissue in CD-MAT vs. CF, CD-MAT vs. H-MAT and CF vs. H-MAT (n = 15–20 per group). Differentially expressed lipid metabolites were detected based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC‒MS/MS). f Schematic of the experimental design for scRNA sequencing. Human mesenteric adipose tissue samples were isolated from H-MAT, CD-MAT and CF, dissociated into single-cell suspensions, and analysed using 10× Genomics Chromium droplet scRNA sequencing. Cells were clustered via differential gene expression and ligand‒receptor analysis was performed to assess interactions among cell types. Source data are provided as a Source data file.