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. 2023 Sep 20;13:15620. doi: 10.1038/s41598-023-42925-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of varying expression of MANII and cGNTIII genes on Rituximab production and N-glycosylation levels. All stable pools expressing mAbs and different levels of MANII and cGNTIII were subjected to seven-day fed-batch production. (A, B) The integrated viable cell density (IVCD) and specific productivity (qP) of each stable pool were represented as relative change to the control pool. (C) N-glycan profiles of Rituximab produced by combination of different MANII and cGNTIII expression levels were presented in aligned HILIC chromatograms from one replicate stable pool of each condition. (D–F) Relative levels of hybrid bisecting glycans, non-fucosylation and galactosylation of glycoengineered IgG1 produced by combination of different MANII and cGNTIII expression levels.